rna stability การใช้

• Removal of the secondary structure correlated with a decrease in RNA stability.
• TRNA-like structures are required for RNA encapsulation and increase RNA stability.
• To combat this, the 2 position on the ribose is modified to improve RNA stability.
• The secondary structures within the 5'UTR was shown to also play a role in RNA stability.
• However, the anti-hemB was judged the more likely orientation, because it had fewer A-C base pairs, which do not contribute to RNA stability.
• In RNA1 both structural elements within the 3'and 5'UTR are required to translation to occur as the 3'UTR contains the translation enhancer element and the 5'UTR contains structures that aid in recruiting translation factors but also act to increase RNA stability.
• RRM proteins have a variety of RNA binding preferences and functions, and include heterogeneous nuclear ribonucleoproteins ( hnRNPs ), proteins implicated in regulation of alternative splicing ( SR, U2AF2, Sxl ), protein components of small nuclear ribonucleoproteins ( U1 and U2 snRNPs ), and proteins that regulate RNA stability and translation ( PABP, La, Hu ).